Related Concept Protein isoform

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a glycoform isoform of protein differs respect number or type of attached glycan. glycoproteins consist of number of different glycoforms, alterations in attached saccharide or oligosaccharide. these modifications may result differences in biosynthesis during process of glycosylation, or due action of glycosidases or glycosyltransferases. glycoforms may detected through detailed chemical analysis of separated glycoforms, more conveniently detected through differential reaction lectins, in lectin affinity chromatography , lectin affinity electrophoresis. typical examples of glycoproteins consisting of glycoforms blood proteins orosomucoid, antitrypsin, , haptoglobin. unusual glycoform variation seen in neuronal cell adhesion molecule, ncam involving polysialic acids, psa.***







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